SCHEMBL9706687

SCHEMBL9706687

Cn1c2c(c(=O)n(-c3cc(C(=O)O)c(Cl)cc3F)c1=O)CCCC2

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CMA1 P23946 1/20 0.34
RXFP1 Q9HBX9 1/20 0.33
EPHX2 P34913 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
KMT2A Q03164 1/20 0.33
FABP4 P15090 3/20 0.32
TSHR P16473 2/20 0.32
MAPT P10636 1/20 0.32
FABP3 P05413 1/20 0.31
RORC P51449 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9706554 0.98 HPGD (0.34) HPGDSMN1; SMN2CMA1RXFP1EPHX2
SCHEMBL10645585 0.97 HPGD (0.34) HPGDSMN1; SMN2CMA1RXFP1EPHX2
SCHEMBL9423141 0.89 TSHR (0.36) HPGDSMN1; SMN2RXFP1ALDH1A1TSHR
SCHEMBL10873317 0.87 RXRA (0.34) CMA1RXFP1MEN1LMNAKMT2A
SCHEMBL9706680 0.87 LMNA (0.37) CMA1RXFP1MEN1ALDH1A1LMNA
SCHEMBL10645580 0.87 HPGD (0.31) HPGDSMN1; SMN2RXFP1TSHRMAPT
SCHEMBL9706633 0.86 HPGD (0.34) HPGDSMN1; SMN2MEN1ALDH1A1LMNA
SCHEMBL9706675 0.86 PPOX (0.36) HPGDSMN1; SMN2RXFP1LMNAMAPT
SCHEMBL9706682 0.85 TSHR (0.33) HPGDSMN1; SMN2EPHX2MEN1ALDH1A1
SCHEMBL9706623 0.84 TTR (0.32) SMN1; SMN2CMA1RXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0195346-B1 3-ARYL URACILES AND THEIR USE AS HERBICIDES CIBA-GEIGY AG (CH) 1992-06-24 EP claimed