Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.64 |
| ▸ | RAB9A | P51151 | 11/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964145 | 0.86 | MAPK9 (0.53) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL15178350 | 0.82 | MAPK9 (0.50) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL28741285 | 0.76 | DAPK3 (0.49) | NPC1RAB9AKMT2AMEN1JAK2 | |
| SCHEMBL18209619 | 0.76 | FABP4 (0.51) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL1920761 | 0.75 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2PKMKMT2A | |
| SCHEMBL1962230 | 0.75 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2TP53KMT2A | |
| SCHEMBL4341336 | 0.73 | RAB9A (0.79) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL18787586 | 0.72 | PTGS2 (0.53) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL7791720 | 0.72 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL7928874 | 0.71 | DHODH (0.61) | NPC1RAB9ASMN1; SMN2TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |