SCHEMBL9710248

SCHEMBL9710248

O=c1ccc(C(F)(F)F)co1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CTRC Q99895 1/20 0.40
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
CYP1A2 P05177 1/20 0.36
AHR P35869 1/20 0.35
NOTUM Q6P988 1/20 0.35
PIK3CA P42336 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TSHR P16473 1/20 0.35
KIF11 P52732 1/20 0.34
EPHX2 P34913 1/20 0.34
FBP1 P09467 1/20 0.34
BACE1 P56817 1/20 0.34
PGR P06401 1/20 0.34
ORAI1 Q96D31 1/20 0.33
ORAI2 Q96SN7 1/20 0.33
ORAI3 Q9BRQ5 1/20 0.33
TRPV6 Q9H1D0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22931373 0.74 CTRC (0.39) CTRCCYP1A2ALDH1A1TSHR
SCHEMBL63468 0.66 ALDH1A1 (0.67) CES2CES1ALDH1A1TSHRKIF11
SCHEMBL7790899 0.66 ALDH1A1 (0.50) CES2CES1ALDH1A1TSHRKIF11
SCHEMBL13569210 0.66 CTRC (0.76) CTRCALDH1A1TSHRPGR
SCHEMBL4516047 0.65 CES2 (0.39) CES2NOTUMTSHRPGR
SCHEMBL15842571 0.64 PGR (0.58) CYP1A2ALDH1A1BACE1PGR
Hydrochloric Acid SCHEMBL28507534 0.64 ALDH1A1 (0.48) CES2CES1ALDH1A1TSHRKIF11
SCHEMBL28990014 0.64 ALDH1A1 (0.48) CES2CES1ALDH1A1TSHRKIF11
SCHEMBL31328606 0.64 ALDH1A1 (0.48) CES2CES1ALDH1A1TSHRKIF11
Hydrochloric Acid SCHEMBL28200992 0.64 ALDH1A1 (0.48) CES2CES1ALDH1A1TSHRKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4249009-A Processes for preparing 2-chloro-5-trifluoromethylpyridine REILLY TAR & CHEMICAL CORP. (US) 1981-02-03 US claimed
US-5158829-A Electroactive ultra-thin layers CIBA-GEIGY CORPORATION (US) 1992-10-27 US disclosed
US-5108841-A Tetrathio or tetraseleno tetracene derivatives; electronics CIBA-GEIGY CORPORATION (US) 1992-04-28 US disclosed
US-5011944-A Substituted α-pyrones CIBA-GEIGY CORPORATION (US) 1991-04-30 US disclosed
US-4940516-A Process for the preparation of electroactive Langmuir-Blodgett layer system CIBA-GEIGY CORPORATION (US) 1990-07-10 US disclosed
EP-0350451-A2 Method for the production of electro-active Langmuir-Blodgett films CIBA-GEIGY AG (CH) 1990-01-10 EP disclosed
EP-0344113-A2 Substituted alpha-pyrones and naphthoquinones CIBA-GEIGY AG (CH) 1989-11-29 EP disclosed
EP-0344108-A2 Electrically active ultrathin films CIBA-GEIGY AG (CH) 1989-11-29 EP disclosed
US-4249009-A Processes for preparing 2-chloro-5-trifluoromethylpyridine REILLY TAR & CHEMICAL CORP. (US) 1981-02-03 US disclosed
US-4249009-A Processes for preparing 2-chloro-5-trifluoromethylpyridine REILLY TAR & CHEMICAL CORP. (US) 1981-02-03 US disclosed
US-4230864-A Process for making 5-trifluoromethyl pyridone REILLY TAR & CHEMICAL CORP. (US) 1980-10-28 US disclosed
US-4230864-A Process for making 5-trifluoromethyl pyridone REILLY TAR & CHEMICAL CORP. (US) 1980-10-28 US disclosed