Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17718796 | 0.77 | ALDH1A1 (0.39) | TSHRCA1CA9MAPK1HSD17B10 | |
| SCHEMBL30742413 | 0.69 | MAOA (0.62) | HSD17B10MAOAMAOBKDM4E | |
| SCHEMBL28465411 | 0.69 | MAOA (0.62) | HSD17B10MAOAMAOBKDM4E | |
| SCHEMBL17708944 | 0.69 | MAOA (0.62) | HSD17B10MAOAMAOBKCNA3KCNA5 | |
| SCHEMBL30395860 | 0.69 | MAOA (0.62) | HSD17B10MAOAMAOBKCNA3KCNA5 | |
| SCHEMBL20858618 | 0.65 | EPM2A (0.45) | PGRHSD17B10MAOAMAOBKDM4E | |
| SCHEMBL827855 | 0.65 | EPM2A (0.62) | PGRMAOAMAOB | |
| SCHEMBL9710248 | 0.65 | CTRC (0.40) | CES2PGRTSHRNOTUM | |
| SCHEMBL1700927 | 0.64 | MAPT (0.36) | KDM4E | |
| SCHEMBL1263945 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232416-A | A method of synthesis 4- trifluoromethyl -2- pyranone/pyridinone compounds | 福州大学 | 2019-01-18 | — | — | CN | claimed |
| CN-109232416-B | Method for synthesizing 4-trifluoromethyl-2-pyrone/pyridone compound | 福州大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-109232416-B | Method for synthesizing 4-trifluoromethyl-2-pyrone/pyridone compound | 福州大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-109232416-B | Method for synthesizing 4-trifluoromethyl-2-pyrone/pyridone compound | 福州大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-109232416-A | A method of synthesis 4- trifluoromethyl -2- pyranone/pyridinone compounds | 福州大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-109232416-A | A method of synthesis 4- trifluoromethyl -2- pyranone/pyridinone compounds | 福州大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-109232416-A | A method of synthesis 4- trifluoromethyl -2- pyranone/pyridinone compounds | 福州大学 | 2019-01-18 | — | — | CN | disclosed |
| US-7488828-B2 | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone | DOW AGROSCIENCES LLC (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488828-B2 | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone | DOW AGROSCIENCES LLC (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488828-B2 | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone | DOW AGROSCIENCES LLC (US) | 2009-02-10 | — | — | US | disclosed |
| WO-2009006211-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE | DOW AGROSCIENCES LLC (US) | 2009-01-08 | — | — | WO | disclosed |
| US-20090005569-A1 | PROCESS FOR THE PREPARATION OF 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE | DOW AGROSCIENCES LLS (US) | 2009-01-01 | — | — | US | disclosed |
| US-20090005569-A1 | PROCESS FOR THE PREPARATION OF 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE | DOW AGROSCIENCES LLS (US) | 2009-01-01 | — | — | US | disclosed |
| WO-2006012320-A1 | PROCESS FOR THE PREPARATION OF 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE | DOW AGROSCIENCES LLC (US) | 2006-02-02 | — | — | WO | disclosed |
| US-20050288511-A1 | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone | CORTEVA AGRISCIENCE LLC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288511-A1 | Process for the preparation of 4-trifluoromethyl-2(1H)-pyridinone | PDXK, PFKFB1, PFKFB4 | CES2 4153/4885NOS3 4062/4885NOS2 4454/4885 |
| US-20090005569-A1 | PROCESS FOR THE PREPARATION OF 4-TRIFLUOROMETHYL-2(1H)-PYRIDINONE | CYP4F2, CYP4F3, CYP4F8 | CES2 1450/4885NOS3 4621/4885NOS2 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.