SCHEMBL9711595

SCHEMBL9711595

CCOc1ccccc1C(=O)C1C(=O)CC(c2ccccc2)NC1=O

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.40
KDM4E B2RXH2 1/20 0.40
HTT P42858 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
NPSR1 Q6W5P4 3/20 0.39
LMNA P02545 3/20 0.39
LDHA P00338 1/20 0.39
TSHR P16473 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
GLA P06280 1/20 0.38
NOD2 Q9HC29 1/20 0.38
KCNA3 P22001 1/20 0.38
CHRM2 P08172 1/20 0.38
CHRM3 P20309 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9711787 0.87 LDHA (0.41) HTTLDHATSHRMAPT
SCHEMBL9711658 0.82 HSD11B1 (0.40) HCRTR1LDHA
SCHEMBL9711646 0.81 ITGB1 (0.42) MEN1KMT2ALMNALDHA
SCHEMBL9711543 0.79 LDHA (0.44) LMNALDHA
SCHEMBL9711629 0.78 ALDH1A1 (0.38) MEN1KMT2ALMNALDHA
SCHEMBL9711577 0.78 SMN1; SMN2 (0.37) TDP1MEN1KMT2ALMNALDHA
SCHEMBL9711557 0.78 ALDH1A1 (0.39) MEN1KMT2ALMNALDHA
SCHEMBL9711668 0.77 KDM4E (0.47) HCRTR1KDM4EHTTTDP1MEN1
SCHEMBL9711454 0.76 MAPT (0.44) HTTMEN1KMT2ALMNALDHA
SCHEMBL9711749 0.75 LMNA (0.38) LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5114461-A Herbicides MAY & BAKER LIMITED (GB) 1992-05-19 US disclosed
EP-0278742-A2 Cyclic diones MAY & BAKER LIMITED (GB) 1988-08-17 EP disclosed