Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.45 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713906 | 0.81 | L3MBTL1 (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP2C19 | |
| SCHEMBL9713772 | 0.80 | HTR6 (0.50) | ABCC9ABCC8KCNJ11KCNJ8CYP2C19 | |
| SCHEMBL9713763 | 0.80 | HSD11B1 (0.48) | ABCC9ABCC8KCNJ11KCNJ8CYP2C19 | |
| SCHEMBL9713943 | 0.78 | CYP2C19 (0.43) | CYP2C19CYP3A4CYP2C9L3MBTL1PKM | |
| SCHEMBL9714032 | 0.77 | FFAR4 (0.44) | CYP2C19L3MBTL1PKMLMNAHSD11B1 | |
| SCHEMBL9714037 | 0.77 | PKM (0.46) | CYP2C19CYP3A4CYP2C9L3MBTL1PKM | |
| SCHEMBL9713905 | 0.77 | PKM (0.46) | CYP2C19KDM4ECYP3A4CYP2C9L3MBTL1 | |
| SCHEMBL9713798 | 0.75 | CDK1 (0.52) | CYP2C19KDM4EL3MBTL1PKMALDH1A1 | |
| SCHEMBL9587134 | 0.73 | CYP1A2 (0.43) | KDM4ECYP3A4POLBMEN1KMT2A | |
| SCHEMBL10692275 | 0.72 | ALDH1A1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5084449-A | Bactericides and antiprotozoa agents | DR. KARL THOMAE GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4992430-A | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase | DR. KARL THOMAE GMBH (DE) | 1991-02-12 | — | — | US | disclosed |
| US-4829058-A | INHIBITORS OF BACTERIA, MYCOBACTERIA AND PLASMODIA | DR. KARL THOMAE GMBH (DE) | 1989-05-09 | — | — | US | disclosed |