SCHEMBL9714028

SCHEMBL9714028

Cc1cc2c(cc1C)C(=O)C(OC(C)C)=CC2=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 3/20 0.42
IDO1 P14902 2/20 0.42
CDC25A P30304 2/20 0.42
GAPDH P04406 2/20 0.40
S100A4 P26447 1/20 0.36
PTPN1 P18031 1/20 0.34
NQO1 P15559 2/20 0.33
POR P16435 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
MAOA P21397 2/20 0.33
MAOB P27338 2/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 1/20 0.33
PLIN1 O60240 1/20 0.33
NR1I2 O75469 1/20 0.33
USP2 O75604 1/20 0.33
GSR P00390 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10706935 0.83 GAPDH (0.60) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL8582314 0.81 IDO1 (0.58) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL30004088 0.81 IDO1 (0.58) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL9713379 0.80 S100A4 (0.44) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL8744491 0.79 CDC25B (0.67) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL10446705 0.77 IDO1 (0.50) CDC25BIDO1CDC25AGAPDHPTPN1
SCHEMBL9629429 0.76 CDC25B (0.49) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL9714130 0.74 ELANE (0.38) CDC25BIDO1CDC25AGAPDHS100A4
SCHEMBL12228754 0.73 ACHE (0.41) NQO1PORALDH1A1HPGDMAOA
SCHEMBL10446180 0.73 CDC25B (0.35) CDC25BIDO1CDC25APTPN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5091558-A Topical administeration SYNTEX (U.S.A.) INC. (US) 1992-02-25 US disclosed
EP-0150831-B1 NAPHTHALENE ANTI-PSORIATIC AGENTS SYNTEX (U.S.A.) INC. (US) 1988-08-10 EP disclosed
EP-0150831-A2 Naphthalene anti-psoriatic agents SYNTEX (U.S.A.) INC. (US) 1985-08-07 EP disclosed