Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714457 | 0.89 | GRM2 (0.43) | GRM2KDM5BKDM4AKDM5AKDM4C | |
| SCHEMBL9714348 | 0.83 | KDM5B (0.54) | KDM5BKDM4AKDM5AKDM4CAURKA | |
| SCHEMBL10570251 | 0.81 | ALDH1A1 (0.48) | GRM2KDM4ESMN1; SMN2KDM5BPTGER1 | |
| SCHEMBL31333083 | 0.80 | PPARG (0.40) | GRM2KDM4ESMN1; SMN2KDM4CAURKA | |
| SCHEMBL31478624 | 0.79 | KDM5B (0.46) | KDM4ESMN1; SMN2KDM5BKDM4AKDM5A | |
| SCHEMBL15965384 | 0.78 | KDM4C (0.57) | GRM2SMN1; SMN2KDM4CAURKARPS6KB1 | |
| SCHEMBL9714289 | 0.78 | CA5A (0.45) | GRM2KDM5BKDM4AKDM5AKDM4C | |
| SCHEMBL9714533 | 0.77 | GRM2 (0.48) | GRM2KDM5BKDM4AKDM5AKDM4C | |
| SCHEMBL9714146 | 0.76 | CA5A (0.58) | GRM2KDM5BKDM4AKDM5AKDM4C | |
| SCHEMBL9857419 | 0.76 | CA5A (0.61) | GRM2KDM4ESMN1; SMN2AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |