Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.54 |
| ▸ | KDM5A | P29375 | 2/20 | 0.54 |
| ▸ | KDM4A | O75164 | 1/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | ADA | P00813 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714289 | 0.89 | CA5A (0.45) | KDM5BKDM5AKDM4AKDM4CCA5A | |
| SCHEMBL9714146 | 0.84 | CA5A (0.58) | KDM5BKDM5AKDM4AKDM4CCA5A | |
| SCHEMBL9714457 | 0.83 | GRM2 (0.43) | KDM5BKDM5AKDM4AKDM4CCA5A | |
| SCHEMBL9714527 | 0.83 | GRM2 (0.43) | KDM5BKDM5AKDM4AKDM4CALDH1A1 | |
| SCHEMBL9714098 | 0.83 | LMNA (0.50) | KDM5BKDM5AKDM4CADALMNA | |
| SCHEMBL9714504 | 0.83 | CYP11B1 (0.47) | KDM5BKDM5AKDM4AKDM4CADA | |
| SCHEMBL10568691 | 0.82 | KDM5A (0.51) | KDM5BKDM5AKDM4AKDM4CALDH1A1 | |
| SCHEMBL15964744 | 0.79 | RBP4 (0.54) | KDM5BKDM5AKDM4AKDM4CADA | |
| SCHEMBL31333075 | 0.78 | MAPT (0.45) | KDM5BKDM5AKDM4AKDM4CMAOB | |
| SCHEMBL2968205 | 0.77 | ALDH1A1 (0.51) | KDM5BKDM5AKDM4AKDM4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | claimed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | claimed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | claimed |
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |