Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 2/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9714706 | 0.87 | MAOA (0.34) | CYP3A4TDP1TSHRKDM4EALDH1A1 | |
| SCHEMBL9714753 | 0.78 | NLRP3 (0.33) | MEN1KMT2AKDM4EALDH1A1PKM | |
| SCHEMBL9714810 | 0.75 | ENPP2 (0.42) | MEN1KMT2ACYP3A4TDP1TSHR | |
| SCHEMBL9714742 | 0.74 | MAOB (0.37) | MEN1KMT2ACYP3A4TDP1TSHR | |
| SCHEMBL27280793 | 0.73 | SIGMAR1 (0.46) | TDP1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL9714580 | 0.73 | MEN1 (0.35) | MEN1KMT2AKDM4EALDH1A1PKM | |
| SCHEMBL27480698 | 0.72 | NFE2L2 (0.50) | TSHRKDM4EALDH1A1PKMMAOA | |
| SCHEMBL9714736 | 0.72 | MAOA (0.42) | CYP3A4TDP1TSHRALDH1A1MAOA | |
| SCHEMBL9714805 | 0.72 | GUSB (0.38) | — | |
| SCHEMBL2647971 | 0.70 | CYP3A4 (0.43) | MEN1KMT2ACYP3A4TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0397697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-07-03 | — | — | EP | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0397697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4?. | RORER INT OVERSEAS (US) | 1990-11-22 | — | — | EP | disclosed |
| WO-1989004304-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |