Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325484 | 0.76 | ADRA2A (0.47) | SIRT1ADRA2AADRA2BADRA2CMTNR1A | |
| SCHEMBL7880454 | 0.68 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CMTNR1AMTNR1B | |
| SCHEMBL9715417 | 0.65 | CYP1A2 (0.36) | KDM4EALDH1A1SMN1; SMN2NPSR1HPGD | |
| SCHEMBL9520939 | 0.65 | KDM4E (0.39) | SIRT1ADRA2AADRA2BADRA2CMTNR1A | |
| SCHEMBL12553115 | 0.63 | NQO2 (0.40) | KDM4EALDH1A1NPSR1KMT2AMAPT | |
| SCHEMBL10750262 | 0.63 | SIRT1 (0.39) | SIRT1KDM4EALDH1A1NPSR1KMT2A | |
| SCHEMBL26581069 | 0.62 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL9814122 | 0.62 | KCNH2 (0.39) | SIRT1ADRA2AADRA2BADRA2CMTNR1A | |
| SCHEMBL3900421 | 0.62 | TAS1R3 (0.45) | SIRT1ALDH1A1USP2 | |
| SCHEMBL11524271 | 0.61 | SIRT1 (0.43) | SIRT1KDM4EALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140040-A | Alpha-2-adrenergic receptor antagonist; glaucoma; congestive heart failure; hypotensive agents; headaches; metabolic disorders (diabetes, obesity) | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5128362-A | Antidepressant, antiglaucoma | ABBOTT LABORATORIES (US) | 1992-07-07 | — | — | US | disclosed |
| US-5086074-A | Selective adrenergic receptor antagonists | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |