Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10463166 | 0.91 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ALMNATP53 | |
| SCHEMBL9718429 | 0.89 | TBXA2R (0.59) | ALDH1A1MEN1KMT2ASMN1; SMN2AKR1C3 | |
| SCHEMBL9718387 | 0.89 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL9660574 | 0.88 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2ALMNATP53 | |
| SCHEMBL10463248 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KMT2ALMNASMN1; SMN2AKR1C3 | |
| SCHEMBL10461125 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ALMNATP53 | |
| SCHEMBL7400490 | 0.83 | ALDH1A1 (0.71) | ALDH1A1MEN1KMT2ALMNATP53 | |
| SCHEMBL9718367 | 0.82 | TBXAS1 (0.58) | TBXA2RTBXAS1 | |
| SCHEMBL10463160 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL10461761 | 0.82 | TBXA2R (0.56) | ALDH1A1MEN1KMT2ALMNAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260527-B1 | SYNERGETIC COMBINATION COMPRISING A PHOSPHODIESTERASE INHIBITOR AND A THROMBOXAN-A2-ANTAGONIST, AND THEIR USE OR MANUFACTURE | Dr. Karl Thomae GmbH (DE) | 1992-04-01 | — | — | EP | disclosed |
| EP-0260527-A2 | Synergetic combination comprising a phosphodiesterase inhibitor and a thromboxan-A2-antagonist, and their use or manufacture | Dr. Karl Thomae GmbH (DE) | 1988-03-23 | — | — | EP | disclosed |
| EP-0194548-A2 | Sulfonylaminoethyl compounds, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-09-17 | — | — | EP | disclosed |