Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.35 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.35 |
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL9719287 | 0.87 | HCAR2 (0.44) | ALDH1A1HCAR2TSHRKMT2AKDM4E | |
| Fumaric Acid SCHEMBL9719235 | 0.85 | HSD17B10 (0.44) | ALDH1A1HCAR2TSHRKMT2AKDM4E | |
| Fumaric Acid SCHEMBL9719239 | 0.85 | HSD17B10 (0.44) | ALDH1A1HCAR2TSHRKMT2AKDM4E | |
| Fumaric Acid SCHEMBL9719243 | 0.85 | HSD17B10 (0.44) | ALDH1A1HCAR2TSHRKMT2AKDM4E | |
| Maleic Acid SCHEMBL9719226 | 0.85 | HSD17B10 (0.44) | ALDH1A1HCAR2TSHRKMT2AKDM4E | |
| Acrylic Acid SCHEMBL6667897 | 0.80 | HSD17B10 (0.42) | ALDH1A1TSHRKMT2ALMNAMEN1 | |
| Tetraethylene Glycol SCHEMBL29064118 | 0.80 | ALDH1A1 (0.56) | ALDH1A1TSHRKMT2AGAALMNA | |
| Fumaric Acid SCHEMBL9719211 | 0.79 | HSD17B10 (0.34) | — | |
| Hexaethylene Glycol SCHEMBL9719257 | 0.79 | HSD17B10 (0.34) | — | |
| Fumaric Acid SCHEMBL9719203 | 0.79 | HSD17B10 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162402-A | For concrete containing a polymeric composition | SANDOZ LTD. (CH) | 1992-11-10 | — | — | US | claimed |
| US-5162402-A | For concrete containing a polymeric composition | SANDOZ LTD. (CH) | 1992-11-10 | — | — | US | disclosed |