Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930666 | 0.78 | TSHR (0.36) | TSHRALDH1A1HPGDTP53MEN1 | |
| SCHEMBL8930681 | 0.74 | TSHR (0.34) | TSHRALDH1A1LMNA | |
| SCHEMBL8930729 | 0.67 | TSHR (0.33) | TSHRALDH1A1HPGDMEN1LMNA | |
| Tromethamine SCHEMBL9719303 | 0.60 | MEN1 (0.33) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL4938995 | 0.56 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5710709 | 0.55 | LMNA (0.67) | ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL27583225 | 0.55 | GAA (0.44) | TSHRALDH1A1TP53HSD17B10LMNA | |
| Tromethamine SCHEMBL1019777 | 0.55 | MEN1 (0.77) | TSHRALDH1A1MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL571834 | 0.55 | MEN1 (0.77) | TSHRALDH1A1MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL5916838 | 0.54 | MEN1 (0.56) | ALDH1A1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515458-A1 | TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI. | HAFSLUND NYCOMED INNOVATION (SE) | 1992-12-02 | — | — | EP | disclosed |
| WO-1991012024-A1 | TRIARYLMETHYL RADICALS AND THE USE OF INERT CARBON FREE RADICALS IN MRI | HAFSLUND NYCOMED INNOVATION AB (SE) | 1991-08-22 | — | — | WO | disclosed |