Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PTPRS | Q13332 | 1/20 | 0.41 |
| ▸ | RGS17 | Q9UGC6 | 1/20 | 0.41 |
| ▸ | CD38 | P28907 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 6/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721302 | 0.84 | TLR8 (0.35) | MAPTHPGDALOX15HSD17B10KDM4E | |
| SCHEMBL9721311 | 0.79 | MAOA (0.36) | CYP3A4PIM1APP | |
| SCHEMBL9721418 | 0.75 | CA1 (0.36) | MAPTHPGDALOX15RECQLHSD17B10 | |
| SCHEMBL9721278 | 0.69 | KDM4E (0.40) | MAPTHPGDALOX15RECQLHSD17B10 | |
| SCHEMBL9721297 | 0.67 | CA1 (0.43) | MAPTHPGDALOX15HSD17B10KDM4E | |
| SCHEMBL9721286 | 0.66 | APP (0.60) | MAPTSNCAAPP | |
| SCHEMBL9721291 | 0.64 | TLR8 (0.36) | MAPTHPGDALOX15HSD17B10TDP1 | |
| SCHEMBL6244870 | 0.64 | BACE1 (0.46) | MAPTHPGDKDM4EMEN1ALDH1A1 | |
| SCHEMBL25183526 | 0.64 | SELL (0.53) | MAPTHPGDALOX15RECQLHSD17B10 | |
| SCHEMBL17322417 | 0.63 | APP (0.48) | MAPTALOX15HSD17B10MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |