Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721245 | 0.79 | MAPT (0.41) | PIM1CYP3A4APP | |
| SCHEMBL9721302 | 0.79 | TLR8 (0.35) | ESR1ESR2PIM1CYP3A4TLR8 | |
| SCHEMBL9721418 | 0.78 | CA1 (0.36) | ESR1ESR2CYP3A4TLR8 | |
| SCHEMBL9721297 | 0.74 | CA1 (0.43) | ACHEESR1ESR2PIM1CYP3A4 | |
| SCHEMBL9721235 | 0.72 | ERN1 (0.41) | MAOAPIM1 | |
| SCHEMBL9721291 | 0.71 | TLR8 (0.36) | ESR1ESR2CYP3A4COMTTLR8 | |
| SCHEMBL9721345 | 0.70 | ACHE (0.38) | MAOAACHEABCB1CYP3A4 | |
| SCHEMBL13695148 | 0.66 | ACHE (0.65) | ACHEESR1CYP3A4APP | |
| SCHEMBL29006355 | 0.66 | ESR2 (0.41) | ESR1ESR2CYP3A4 | |
| SCHEMBL11802995 | 0.64 | ESR1 (0.46) | ESR1ESR2PIM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |