Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CASP9 | P55211 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852644 | 0.88 | CASP7 (0.53) | PARP1AHRPDK2SRCCASP7 | |
| SCHEMBL88280 | 0.80 | MAPT (0.47) | AHRPDK2SRCMAPTNPC1 | |
| SCHEMBL29896031 | 0.80 | MAPT (0.47) | AHRPDK2SRCMAPTNPC1 | |
| SCHEMBL22904534 | 0.78 | PARP1 (0.54) | PARP1CASP7TDP2CASP3CASP9 | |
| SCHEMBL2087698 | 0.78 | TDP2 (0.66) | PARP1AHRPDK2SRCCASP7 | |
| SCHEMBL11673017 | 0.75 | MAOA (0.61) | PARP1MAOAMAOBMAPTNPC1 | |
| SCHEMBL221400 | 0.74 | PNMT (0.58) | PARP1MAOAMAPTNPC1KDM4E | |
| SCHEMBL30497776 | 0.74 | PNMT (0.58) | PARP1MAOAMAPTNPC1KDM4E | |
| Bromide SCHEMBL28349432 | 0.72 | PNMT (0.56) | PARP1MAOAMAPTNPC1KDM4E | |
| SCHEMBL29757969 | 0.72 | NPC1 (0.50) | AHRPDK2SRCCASP7TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5080905-A | THERAPY OF 10-AMINO-5,6-DIHYDRO-11H-DIBENZO(B,E)AZEPINE-6,11-DIONE AND DERIVATIVES AS DRUGS FOR USE IN THE TREATMENT OF URINARY INCONTINENCE | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.T.L. (IT) | 1992-01-14 | — | — | US | disclosed |