Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.73 |
| ▸ | DRD4 | P21917 | 4/20 | 0.71 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727049 | 0.93 | MAOB (0.80) | MAOBDRD4MAOASIGMAR1MCHR1 | |
| SCHEMBL9727095 | 0.83 | DRD4 (0.72) | MAOBDRD4SIGMAR1MCHR1ACHE | |
| SCHEMBL9727125 | 0.82 | KDM4E (0.68) | MAOBDRD4SIGMAR1MCHR1ACHE | |
| SCHEMBL9727136 | 0.80 | DRD4 (0.67) | MAOBDRD4ACHE | |
| SCHEMBL9872559 | 0.80 | DRD4 (0.78) | DRD4SIGMAR1MCHR1ACHE | |
| SCHEMBL9727091 | 0.79 | DRD4 (0.70) | MAOBDRD4SIGMAR1MCHR1ACHE | |
| SCHEMBL9727133 | 0.79 | DRD4 (0.66) | MAOBDRD4SIGMAR1MCHR1ACHE | |
| SCHEMBL30569390 | 0.79 | MAOB (0.60) | MAOBKCNH2 | |
| SCHEMBL9852057 | 0.76 | DRD4 (0.67) | DRD4SIGMAR1MCHR1 | |
| SCHEMBL9727102 | 0.76 | SIGMAR1 (0.72) | DRD4SIGMAR1MCHR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |