Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727135 | 0.88 | DRD4 (0.67) | DRD4MCHR1MAOBSIGMAR1 | |
| SCHEMBL9727173 | 0.87 | SIGMAR1 (0.57) | DRD4MCHR1MAOBSIGMAR1 | |
| SCHEMBL9727123 | 0.87 | DRD4 (0.69) | DRD4MCHR1MAOBSIGMAR1 | |
| Dimethylamine SCHEMBL9852061 | 0.87 | DRD4 (0.63) | DRD4MCHR1MAOBKMT2ASIGMAR1 | |
| SCHEMBL9483648 | 0.87 | DRD4 (0.52) | DRD4MCHR1MAOBKMT2A | |
| SCHEMBL9727095 | 0.86 | DRD4 (0.72) | DRD4MCHR1MAOBSIGMAR1ALDH1A1 | |
| SCHEMBL9727255 | 0.83 | DRD4 (0.66) | DRD4MAOBSIGMAR1 | |
| SCHEMBL9727149 | 0.82 | DRD4 (0.58) | DRD4MCHR1MAOBKMT2ASIGMAR1 | |
| SCHEMBL9852055 | 0.80 | MCHR1 (0.66) | DRD4KCNH2MCHR1MAOBDRD3 | |
| SCHEMBL9852082 | 0.79 | DRD4 (0.73) | DRD4KCNH2MCHR1MAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |