Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.55 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727392 | 0.98 | LMNA (0.59) | LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G | |
| SCHEMBL9727309 | 0.87 | HTR6 (0.49) | LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G | |
| SCHEMBL9727306 | 0.81 | LMNA (0.41) | LMNAHTTSMN1; SMN2APOBEC3AAPOBEC3G | |
| SCHEMBL10702282 | 0.76 | MMP2 (0.64) | KMT2AAKR1C3TP53GAA | |
| SCHEMBL7379601 | 0.76 | MMP2 (0.64) | LMNASMN1; SMN2MEN1KMT2AAKR1C3 | |
| SCHEMBL7383735 | 0.76 | MMP2 (0.64) | LMNAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7380549 | 0.76 | PKM (0.62) | LMNAMEN1KMT2AAKR1C3TP53 | |
| SCHEMBL9727563 | 0.76 | AKR1C3 (0.56) | LMNAHTTSMN1; SMN2AKR1C3TP53 | |
| SCHEMBL9797182 | 0.76 | AKR1C3 (0.56) | LMNAHTTSMN1; SMN2AKR1C3TP53 | |
| SCHEMBL9727446 | 0.74 | MEN1 (0.41) | LMNAHTTSMN1; SMN2TSHRSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | disclosed |
| EP-0335758-A2 | Derivatives of 1-arylsulfonyl-2-pyrolidinone, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-10-04 | — | — | EP | disclosed |