Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727749 | 0.89 | MAOA (0.34) | MAOAMAOBBRD4CREBBPGP6 | |
| SCHEMBL5502488 | 0.85 | MAOA (0.40) | MAOAMAOBHTR6 | |
| SCHEMBL9727339 | 0.81 | MAOB (0.43) | MAOAMAOBHTR6 | |
| SCHEMBL9727458 | 0.81 | PTGER1 (0.47) | — | |
| SCHEMBL5513024 | 0.79 | HPGD (0.32) | — | |
| SCHEMBL9727691 | 0.79 | MTNR1B (0.42) | — | |
| SCHEMBL9727567 | 0.77 | CYP3A4 (0.37) | HTR6 | |
| SCHEMBL14435033 | 0.77 | HTR6 (0.43) | HTR6 | |
| SCHEMBL9727767 | 0.76 | HIF1A (0.36) | HIF1A | |
| SCHEMBL9727765 | 0.76 | MTNR1B (0.39) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |