Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727767 | 0.88 | HIF1A (0.36) | MTNR1BMTNR1AHIF1ACYSLTR2CYSLTR1 | |
| SCHEMBL9727691 | 0.86 | MTNR1B (0.42) | MTNR1BCYSLTR1NPC1MAPTNFKB1 | |
| SCHEMBL9727458 | 0.86 | PTGER1 (0.47) | — | |
| SCHEMBL5502488 | 0.85 | MAOA (0.40) | — | |
| SCHEMBL9727674 | 0.82 | LTB4R (0.38) | — | |
| SCHEMBL9727339 | 0.81 | MAOB (0.43) | — | |
| SCHEMBL5518490 | 0.80 | F2 (0.41) | MTNR1BMTNR1A | |
| SCHEMBL9727664 | 0.80 | MAPK1 (0.38) | MTNR1BMTNR1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14435033 | 0.78 | HTR6 (0.43) | — | |
| SCHEMBL9727567 | 0.77 | CYP3A4 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |