Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.33 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727649 | 0.89 | HIF1A (0.34) | MAOAMAOBBRD4CREBBPGP6 | |
| SCHEMBL5513024 | 0.88 | HPGD (0.32) | — | |
| SCHEMBL5506271 | 0.85 | MAOA (0.41) | MAOAMAOB | |
| SCHEMBL9727677 | 0.79 | PTGDR2 (0.38) | MAOAMAOB | |
| SCHEMBL9727650 | 0.79 | KDM1A (0.41) | CYSLTR1CYSLTR2 | |
| SCHEMBL9727674 | 0.77 | LTB4R (0.38) | MAOAMAOB | |
| SCHEMBL9727669 | 0.77 | MTNR1A (0.43) | — | |
| SCHEMBL14435039 | 0.75 | AKR1B1 (0.40) | — | |
| SCHEMBL27739159 | 0.74 | MAOB (0.41) | MAOAMAOB | |
| SCHEMBL5518490 | 0.73 | F2 (0.41) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |