Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502488 | 0.92 | MAOA (0.40) | MAOBMAOAHTR6 | |
| SCHEMBL9727458 | 0.87 | PTGER1 (0.47) | — | |
| SCHEMBL9727691 | 0.84 | MTNR1B (0.42) | — | |
| SCHEMBL9727567 | 0.83 | CYP3A4 (0.37) | HTR6 | |
| SCHEMBL14435033 | 0.83 | HTR6 (0.43) | HTR6 | |
| SCHEMBL9727649 | 0.81 | HIF1A (0.34) | MAOBMAOAHTR6 | |
| SCHEMBL9727765 | 0.81 | MTNR1B (0.39) | — | |
| SCHEMBL9727767 | 0.81 | HIF1A (0.36) | — | |
| SCHEMBL5518490 | 0.80 | F2 (0.41) | MAOBMAOA | |
| SCHEMBL9727664 | 0.80 | MAPK1 (0.38) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |