Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732893 | 0.76 | MAPT (0.39) | TSHR | |
| SCHEMBL9709901 | 0.73 | SLC1A2 (0.38) | — | |
| SCHEMBL9435413 | 0.72 | CYP3A4 (0.31) | TSHRCYP3A4ATMTDP1 | |
| SCHEMBL9709877 | 0.72 | KMT2A (0.40) | TSHRCYP3A4ATMTDP1 | |
| SCHEMBL9709564 | 0.70 | ALDH1A1 (0.38) | TSHR | |
| SCHEMBL9709607 | 0.70 | NLRP3 (0.32) | — | |
| SCHEMBL9709563 | 0.69 | CA1 (0.42) | TDP1 | |
| SCHEMBL27230119 | 0.67 | TSHR (0.39) | TSHRCYP3A4ATMTDP1 | |
| SCHEMBL5677958 | 0.67 | GRIK1 (0.46) | — | |
| SCHEMBL25185267 | 0.66 | TSHR (0.53) | TSHRCYP3A4ATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153214-A | Treating cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0493324-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1992-07-01 | — | — | EP | disclosed |
| US-5025025-A | Cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0405391-A1 | Certain (arylsulfonamido- and pyridyl- or imidazolyl-)-substituted carboxylic acids and derivatives thereof | CIBA-GEIGY AG (CH) | 1991-01-02 | — | — | EP | disclosed |