Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733503 | 0.82 | ABCC9 (0.38) | ABCC9ABCB1CNR2ABCC8KCNJ11 | |
| SCHEMBL7274240 | 0.80 | ABCC9 (0.62) | ABCC9ABCB1 | |
| SCHEMBL9733792 | 0.78 | CNR2 (0.37) | ABCC9ABCB1CNR2ABCC8KCNJ11 | |
| SCHEMBL9565076 | 0.77 | ABCC9 (0.38) | ABCC9AVPR1AGRM5HCRTR1HCRTR2 | |
| SCHEMBL9565074 | 0.77 | ABCC9 (0.38) | ABCC9AVPR1AGRM5HCRTR1HCRTR2 | |
| SCHEMBL9565078 | 0.77 | ABCC9 (0.38) | ABCC9AVPR1AGRM5HCRTR1HCRTR2 | |
| SCHEMBL9733745 | 0.77 | ABCC9 (0.38) | ABCC9ABCB1CNR2HCRTR2 | |
| SCHEMBL7357182 | 0.74 | ABCC9 (0.45) | ABCC9AVPR1AABCB1ABCC8KCNJ11 | |
| SCHEMBL7360016 | 0.73 | ABCC9 (0.44) | ABCC9AVPR1AABCB1ABCC8KCNJ11 | |
| SCHEMBL9734651 | 0.72 | CNR2 (0.38) | ABCC9ABCB1CNR2ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |