Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.45 |
| ▸ | ICMT | O60725 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734393 | 0.88 | MAPT (0.51) | MAPTTP53PLA2G2AS1PR2ICMT | |
| SCHEMBL9733317 | 0.82 | P2RX7 (0.52) | MAPTPLA2G2AS1PR2ICMTP2RX7 | |
| SCHEMBL9732562 | 0.78 | ICMT (0.48) | MAPTPLA2G2AICMTP2RX7LMNA | |
| SCHEMBL9732159 | 0.76 | KDM4E (0.48) | MAPTTP53PLA2G2AICMTPOLB | |
| SCHEMBL9731975 | 0.74 | P2RX7 (0.54) | MAPTTP53PLA2G2AP2RX7LMNA | |
| SCHEMBL9732575 | 0.74 | ALDH1A1 (0.49) | MAPTTP53PLA2G2APOLBP2RX7 | |
| SCHEMBL9733154 | 0.72 | PLA2G2A (0.50) | TP53PLA2G2AMTNR1AMTNR1BP2RX7 | |
| SCHEMBL9733084 | 0.72 | P2RX7 (0.52) | MAPTTP53PLA2G2AICMTP2RX7 | |
| SCHEMBL5131095 | 0.72 | PLA2G2A (0.52) | MAPTTP53PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL9732157 | 0.71 | PLA2G2A (0.49) | MAPTTP53PLA2G2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992007829-A1 | INDOLE-3-METHANAMINES USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |