Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 2/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | WNT3 | P56703 | 1/20 | 0.31 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735111 | 0.93 | TPSAB1 (0.41) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| Maleic Acid SCHEMBL9735173 | 0.88 | TPSAB1 (0.47) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| Fumaric Acid SCHEMBL9735177 | 0.88 | TPSAB1 (0.47) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| Maleic Acid SCHEMBL8824254 | 0.87 | ALOX15 (0.45) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| Fumaric Acid SCHEMBL9735611 | 0.83 | TSHR (0.46) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| Fumaric Acid SCHEMBL9735616 | 0.83 | TSHR (0.46) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| SCHEMBL9734807 | 0.82 | GAA (0.46) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| SCHEMBL9735768 | 0.81 | GAA (0.49) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| SCHEMBL9735396 | 0.81 | GAA (0.51) | TPSAB1TPSD1TPSG1TGM2NAMPT | |
| SCHEMBL9735518 | 0.81 | TGM2 (0.45) | TPSAB1TPSD1TPSG1TGM2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102882-A | Nootropic agents | NIPPON SHINYAKU CO., LTD. (JP) | 1992-04-07 | — | — | US | disclosed |