Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.35 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9735173 | 1.00 | TPSAB1 (0.47) | TPSAB1TPSD1TPSG1DDB1CRBN | |
| Maleic Acid SCHEMBL8824254 | 0.88 | ALOX15 (0.45) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| Maleic Acid SCHEMBL9734878 | 0.88 | TPSAB1 (0.40) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| Fumaric Acid SCHEMBL9735611 | 0.84 | TSHR (0.46) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| Fumaric Acid SCHEMBL9735616 | 0.84 | TSHR (0.46) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| SCHEMBL9734807 | 0.83 | GAA (0.46) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| SCHEMBL9735768 | 0.82 | GAA (0.49) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| SCHEMBL9735396 | 0.82 | GAA (0.51) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| SCHEMBL9734899 | 0.81 | GAA (0.54) | TPSAB1TPSD1TPSG1NAMPTPARP1 | |
| SCHEMBL13780327 | 0.80 | TPSAB1 (0.53) | TPSAB1TPSD1TPSG1DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5102882-A | Nootropic agents | NIPPON SHINYAKU CO., LTD. (JP) | 1992-04-07 | — | — | US | disclosed |