Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | MIF | P14174 | 2/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | GPR6 | P46095 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733851 | 0.87 | MAOB (0.34) | ABCC9PGRPOLBCASP3MALT1 | |
| SCHEMBL9733222 | 0.87 | POLB (0.34) | PGRPOLBCASP3MALT1HTR2A | |
| SCHEMBL9734810 | 0.86 | ABCC9 (0.32) | ABCC9PGRPOLBCASP3MALT1 | |
| SCHEMBL9734001 | 0.84 | POLB (0.33) | ABCC9PGRPOLBCASP3NSD2 | |
| SCHEMBL9733322 | 0.84 | KCNJ1 (0.36) | ABCC9PGRKCNH2 | |
| SCHEMBL9733957 | 0.82 | CYP19A1 (0.35) | ABCC9PGRPOLBCASP3MALT1 | |
| SCHEMBL9733284 | 0.82 | HTR1A (0.37) | ABCC9PGRPOLBCASP3NSD2 | |
| SCHEMBL9735233 | 0.81 | PGR (0.36) | PGRDRD2 | |
| SCHEMBL9733247 | 0.81 | VCAM1 (0.39) | ABCC9 | |
| SCHEMBL9733571 | 0.80 | POLB (0.33) | PGRPOLBCASP3NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |