Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734151 | 0.80 | KDM4E (0.42) | KDM4EMPOSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL9734968 | 0.76 | GAA (0.51) | KDM4EMPOMAPTMAPK1LMNA | |
| SCHEMBL9734743 | 0.75 | KDM4E (0.45) | KDM4EMPOSMN1; SMN2ALDH1A1ACHE | |
| SCHEMBL9734073 | 0.70 | ALDH1A1 (0.61) | KDM4EMPOALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL9734834 | 0.70 | MAPT (0.48) | KDM4EMPOALDH1A1HIF1AHSD17B10 | |
| SCHEMBL9735204 | 0.70 | KDM4E (0.47) | KDM4EMPOSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL9733716 | 0.70 | KDM4E (0.47) | KDM4EMPOSMN1; SMN2ALDH1A1HIF1A | |
| SCHEMBL3375026 | 0.69 | ALDH1A1 (0.46) | KDM4ESMN1; SMN2ALDH1A1ACHEMAPT | |
| SCHEMBL1395268 | 0.69 | KDM4E (0.67) | KDM4ESMN1; SMN2ALDH1A1TSHRACHE | |
| SCHEMBL16815109 | 0.68 | ACHE (0.50) | KDM4ESMN1; SMN2ALDH1A1ALOX15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106975-A | Hexahydropyrimidine derivatives | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0434185-A2 | Hexahydropyrimidine derivatives | ETHYL PETROLEUM ADDITIVES, INC. (US) | 1991-06-26 | — | — | EP | disclosed |