Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735247 | 0.85 | ABCC9 (0.34) | KMT2AALDH1A1MEN1ABCC9ABCC8 | |
| SCHEMBL9735600 | 0.83 | ABCC9 (0.51) | DRD2KMT2AALDH1A1MEN1ABCC9 | |
| SCHEMBL9735367 | 0.82 | ALOX15 (0.38) | ALDH1A1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9735806 | 0.81 | DRD2 (0.35) | DRD4DRD2HTR2AKMT2AALDH1A1 | |
| SCHEMBL9734741 | 0.76 | ABCC9 (0.52) | NR1H4HIF1ADRD2HTR2AKMT2A | |
| SCHEMBL9737011 | 0.72 | PNMT (0.34) | DRD2HTR2AALDH1A1L3MBTL1 | |
| SCHEMBL9735385 | 0.72 | ABCC9 (0.39) | NR1H4HIF1AKMT2AALDH1A1MEN1 | |
| SCHEMBL10512066 | 0.69 | ABCC9 (0.44) | HIF1AKMT2AALDH1A1POLBAPEX1 | |
| SCHEMBL10512079 | 0.69 | ABCC9 (0.44) | HIF1AKMT2AALDH1A1POLBAPEX1 | |
| SCHEMBL10510508 | 0.69 | ABCC9 (0.44) | HIF1AKMT2AALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |