Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735552 | 0.86 | IDO1 (0.32) | — | |
| SCHEMBL9738453 | 0.84 | LMNA (0.33) | MAPTSMN1; SMN2LMNA | |
| SCHEMBL9735584 | 0.81 | ALOX5 (0.34) | ALOX5POLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9735313 | 0.81 | ALOX5 (0.32) | ALOX5MAPTRAB9ASMN1; SMN2RARB | |
| SCHEMBL9735212 | 0.80 | CA12 (0.34) | ALOX5POLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9736521 | 0.77 | AXL (0.32) | ALOX5POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL9735222 | 0.75 | RARB (0.33) | ALOX5POLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9735230 | 0.71 | ALOX5 (0.38) | ALOX5MAPTRAB9ASMN1; SMN2RARB | |
| SCHEMBL9735336 | 0.70 | ALOX5 (0.36) | ALOX5POLBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9735486 | 0.70 | ALOX5 (0.36) | ALOX5POLBMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |