Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085342 | 0.87 | ALOX5 (0.39) | ALOX5IDO1EDNRAOPRM1RAB9A | |
| SCHEMBL9740635 | 0.85 | IDO1 (0.35) | IDO1SMN1; SMN2GAA | |
| SCHEMBL9740284 | 0.83 | ALDH1A1 (0.33) | SMN1; SMN2MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL9736924 | 0.83 | ABCC9 (0.40) | LMNAMEN1KMT2A | |
| SCHEMBL9734831 | 0.81 | ALOX5 (0.37) | ALOX5IDO1EDNRAOPRM1RAB9A | |
| SCHEMBL9735947 | 0.80 | ABCC9 (0.39) | IDO1RAB9ASMN1; SMN2RARBRARG | |
| SCHEMBL8090564 | 0.79 | MAPT (0.41) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL7269439 | 0.76 | ABCC9 (0.44) | ALOX5LMNA | |
| SCHEMBL8088411 | 0.76 | KDM4E (0.33) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8088453 | 0.75 | F10 (0.33) | OPRM1SMN1; SMN2ALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |