Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 3/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | MAT2A | P31153 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907930 | 0.87 | HTR2A (0.48) | HTR2AHTR2CNOTUMKMT2AF11 | |
| SCHEMBL235219 | 0.78 | NOTUM (0.59) | HTR2AHTR2CNOTUM | |
| SCHEMBL17907947 | 0.77 | ALDH1A1 (0.38) | NOTUMKMT2ATDP2MAT2A | |
| SCHEMBL9735956 | 0.77 | NOTUM (0.62) | HTR2AHTR2CNOTUMKMT2ATDP2 | |
| SCHEMBL17907932 | 0.71 | SIGMAR1 (0.41) | HTR2AHTR2CNOTUMRXFP1 | |
| SCHEMBL17907920 | 0.68 | HTR2A (0.51) | HTR2AHTR2CKMT2A | |
| SCHEMBL19921327 | 0.66 | HTR2A (0.56) | HTR2AHTR2CKMT2AMAT2A | |
| SCHEMBL17907979 | 0.65 | PTGDR2 (0.39) | HTR2AHTR2CNOTUMKMT2AKMO | |
| SCHEMBL5619809 | 0.65 | HTR2C (1.00) | HTR2AHTR2C | |
| SCHEMBL1770250 | 0.64 | NOTUM (0.35) | NOTUMDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |