Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 9/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | PRKCG | P05129 | 2/20 | 0.36 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | PRKCH | P24723 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 2/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766596 | 0.81 | MAPT (0.55) | WEE1CHEK1ADKMAPTLMNA | |
| SCHEMBL21246791 | 0.71 | MAOA (0.45) | WEE1CHEK1ADKMAPTLMNA | |
| SCHEMBL15431517 | 0.68 | CA2 (0.43) | MAPTLMNAHTTCA2CA4 | |
| SCHEMBL28677769 | 0.67 | GPR84 (0.42) | MAPTLMNAHTTCA2CA4 | |
| SCHEMBL30753519 | 0.66 | CHEK1 (0.52) | WEE1CHEK1ADKMAPTLMNA | |
| SCHEMBL9285018 | 0.66 | ESR1 (0.42) | MAPTLMNAHTTPTGS2CA2 | |
| SCHEMBL18892992 | 0.65 | HTT (0.44) | CHEK1MAPTLMNAHTTMEN1 | |
| SCHEMBL6422263 | 0.63 | KDM4E (0.54) | ADKMAPTLMNAHTTPTGS2 | |
| Phosphoric Acid SCHEMBL5679956 | 0.63 | PDE4A (0.45) | MAPTLMNAHTTCA2CA4 | |
| Phosphoric Acid SCHEMBL1199529 | 0.63 | PDE4A (0.45) | MAPTLMNAHTTCA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5138050-A | 6-amido-1-methyl carbapenems | MERCK & CO., INC. (US) | 1992-08-11 | — | — | US | disclosed |
| WO-1990000170-A1 | NOVEL 6-AMIDO-1-METHYLCARBAPENEMS | MERCK & CO., INC. (US) | 1990-01-11 | — | — | WO | disclosed |
| EP-0350211-A2 | Novel 6-amido-1-methyl carbapenems | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |