Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738190 | 0.74 | RAD52 (0.33) | PAX8PTGES2MEN1KMT2AKDM4E | |
| SCHEMBL10005758 | 0.64 | PAX8 (0.76) | PAX8MEN1KMT2AKDM4EGAA | |
| Hydrochloric Acid SCHEMBL14972550 | 0.63 | PAX8 (0.74) | PAX8MEN1KMT2AKDM4EGAA | |
| SCHEMBL9736655 | 0.63 | KDM4E (0.37) | PTGES2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9737883 | 0.60 | KDM4E (0.63) | PTGES2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL15144855 | 0.60 | PAX8 (0.62) | PAX8MEN1KMT2AKDM4EGAA | |
| SCHEMBL8687445 | 0.60 | PTGES2 (0.43) | PTGES2MEN1KMT2AKDM4EGAA | |
| SCHEMBL19531647 | 0.56 | KDM4E (0.43) | KDM4EGAAALDH1A1 | |
| SCHEMBL26398797 | 0.56 | RORA (0.42) | GAAALDH1A1 | |
| SCHEMBL7749394 | 0.56 | PTGES2 (0.47) | PTGES2KDM4EGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021678-A1 | LIPOXYGENASE INHIBITING PYRROLO [1,2a]INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-12-10 | — | — | WO | disclosed |