Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GOT1 | P17174 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740469 | 0.86 | GAA (0.43) | NPC1POLBSMN1; SMN2 | |
| SCHEMBL9739249 | 0.82 | SLC6A3 (0.40) | NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9740046 | 0.81 | NPC1 (0.37) | NPC1POLBHTTSMN1; SMN2BRD4 | |
| SCHEMBL9739157 | 0.79 | PARP1 (0.39) | NPC1POLBADRB1HTTSMN1; SMN2 | |
| SCHEMBL9740491 | 0.77 | MEN1 (0.40) | NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9738757 | 0.76 | NPC1 (0.43) | NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9738947 | 0.76 | HTT (0.42) | NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9739485 | 0.76 | CYP1A2 (0.37) | NPC1POLBCCNCCDK8HTT | |
| SCHEMBL9738938 | 0.75 | NPC1 (0.40) | NPC1POLBHTTSMN1; SMN2 | |
| SCHEMBL9739705 | 0.74 | MEN1 (0.37) | NPC1POLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |