Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738938 | 0.90 | NPC1 (0.40) | NPC1POLBPARP1SMN1; SMN2HTT | |
| SCHEMBL9740491 | 0.84 | MEN1 (0.40) | NPC1POLBSMN1; SMN2HTTMAPT | |
| SCHEMBL9739497 | 0.83 | MAPT (0.46) | NPC1POLBPARP1SMN1; SMN2HTT | |
| SCHEMBL9738947 | 0.82 | HTT (0.42) | NPC1POLBSMN1; SMN2HTTKMT2A | |
| SCHEMBL9739810 | 0.82 | PARP1 (0.47) | NPC1POLBPARP1OPRM1SIGMAR1 | |
| SCHEMBL9739249 | 0.80 | SLC6A3 (0.40) | NPC1POLBPARP1SMN1; SMN2HTT | |
| SCHEMBL9739723 | 0.80 | LMNA (0.46) | NPC1POLBPARP1SMN1; SMN2HTT | |
| SCHEMBL9738615 | 0.77 | CHRM5 (0.46) | NPC1POLBSMN1; SMN2HTTMAPT | |
| SCHEMBL9739008 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTKMT2AMEN1LMNA | |
| SCHEMBL9738986 | 0.77 | RXFP1 (0.42) | NPC1POLBPARP1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |