Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740686 | 0.86 | HSD11B1 (0.41) | TSHRHSP90AA1KMT2AMAPTMAPK1 | |
| SCHEMBL9711155 | 0.83 | ALDH1A1 (0.39) | TSHRAKR1B1KMT2ALMNAMAPT | |
| SCHEMBL9711152 | 0.83 | HSD11B1 (0.41) | HSP90AA1KMT2AL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL9739733 | 0.80 | HSP90AA1 (0.43) | HSP90AA1AKR1B1KMT2AMAPTMAPK1 | |
| SCHEMBL2643715 | 0.76 | MCOLN3 (0.50) | TSHRMCOLN3PTGES2AKR1B1KMT2A | |
| SCHEMBL18457 | 0.73 | TSHR (0.53) | TSHRMCOLN3PTGES2AKR1B1KMT2A | |
| SCHEMBL29519135 | 0.73 | TSHR (0.53) | TSHRMCOLN3PTGES2AKR1B1KMT2A | |
| SCHEMBL9711252 | 0.73 | TSHR (0.36) | TSHRKMT2APGRL3MBTL1ALDH1A1 | |
| SCHEMBL9711172 | 0.72 | CA1 (0.50) | KMT2AALDH1A1MEN1 | |
| SCHEMBL9711256 | 0.72 | KIF18A (0.37) | TSHRMAPTMAPK1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |