Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 10/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740284 | 0.85 | ALDH1A1 (0.33) | SMN1; SMN2 | |
| SCHEMBL9736924 | 0.85 | ABCC9 (0.40) | — | |
| SCHEMBL9735486 | 0.85 | ALOX5 (0.36) | IDO1GAASMN1; SMN2 | |
| SCHEMBL9736968 | 0.80 | IDO1 (0.38) | IDO1HTR2BXIAPSMN1; SMN2NPSR1 | |
| SCHEMBL9735602 | 0.79 | ABCC9 (0.41) | IDO1HTR2BSMN1; SMN2 | |
| SCHEMBL9143340 | 0.72 | ABCC9 (0.45) | GAA | |
| SCHEMBL9143344 | 0.72 | ABCC9 (0.45) | GAA | |
| SCHEMBL9143349 | 0.72 | ABCC9 (0.45) | GAA | |
| SCHEMBL8088478 | 0.72 | — | — | |
| SCHEMBL8084569 | 0.72 | KMT2A (0.32) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |