Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9652718 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2RAPGEF4ALDH1A1ALOX12CYP3A4 | |
| SCHEMBL3253706 | 0.77 | MEP1B (0.47) | SMN1; SMN2POLBMEP1BRAPGEF4ALDH1A1 | |
| SCHEMBL10407436 | 0.77 | RAPGEF4 (0.50) | SMN1; SMN2POLBMEP1BRAPGEF4ALDH1A1 | |
| SCHEMBL9711160 | 0.77 | RAPGEF4 (0.44) | AKR1B1SMN1; SMN2RAPGEF4ALDH1A1MAPT | |
| SCHEMBL9711140 | 0.76 | ALDH1A1 (0.55) | AKR1B1ALDH1A1MAPTCYP3A4KMT2A | |
| SCHEMBL9740622 | 0.75 | ALDH1A1 (0.40) | AKR1B1POLBALDH1A1CYP3A4TSHR | |
| SCHEMBL9711168 | 0.75 | SOD1 (0.49) | MAPTTSHRKMT2A | |
| SCHEMBL4398061 | 0.74 | MEP1B (0.45) | SMN1; SMN2POLBMEP1BRAPGEF4ALDH1A1 | |
| SCHEMBL6916390 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBMEP1BRAPGEF4ALDH1A1 | |
| SCHEMBL10407448 | 0.73 | RAPGEF4 (0.46) | SMN1; SMN2POLBMEP1BRAPGEF4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153227-A | Treatment of diabetes and galactosemia complications | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-10-06 | — | — | US | disclosed |