Sugi Predict

Sugi Predict / Compounds / SCHEMBL974271

SCHEMBL974271

SCHEMBL974271

CN(C)CCCNc1ccccc1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.47
▸ RAD52 P43351 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ SLC2A1 P11166 1/20 0.47
▸ APOBEC3A P31941 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ APOBEC3G Q9HC16 1/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.45
▸ BRCA1 P38398 1/20 0.45
▸ HIF1A Q16665 1/20 0.45
▸ BRD4 O60885 1/20 0.45
▸ ATAD2 Q6PL18 1/20 0.45
▸ NCF1 P14598 1/20 0.43
▸ TOP2A P11388 1/20 0.42
▸ HDAC6 Q9UBN7 1/20 0.42
▸ CALCA P06881 1/20 0.41
▸ FERMT2 Q96AC1 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30228008 1.00 POLB (0.47) POLBRAD52KMT2ANPC1SLC2A1
SCHEMBL3870508 0.95 TOP2A (0.43) POLBRAD52KMT2ANPC1SLC2A1
SCHEMBL3872395 0.93 HDAC3 (0.43) POLBRAD52KMT2ANPC1SLC2A1
SCHEMBL974274 0.89 NCF1 (0.53) POLBRAD52KMT2ASLC2A1BRD4
SCHEMBL30457115 0.89 NCF1 (0.53) POLBRAD52KMT2ASLC2A1BRD4
Hydrochloric Acid SCHEMBL9725565 0.87 NCF1 (0.51) POLBRAD52KMT2ASLC2A1BRD4
Hydrochloric Acid SCHEMBL9725413 0.87 NCF1 (0.51) POLBRAD52KMT2ASLC2A1BRD4
SCHEMBL3872894 0.83 MAPT (0.47) POLBNPC1RAB9ATOP2AHDAC6
SCHEMBL867417 0.82 PRSS1 (0.47) KMT2ASMN1; SMN2HDAC6ALDH1A1MAPT
SCHEMBL215272 0.82 HDAC3 (0.50) KMT2ASMN1; SMN2HDAC6ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115779140-B Wound dressing containing collagen and preparation method thereof 江苏亨瑞生物医药科技有限公司 2023-05-02 — — CN claimed
CN-115779140-A Wound dressing containing collagen and preparation method thereof 江苏亨瑞生物医药科技有限公司 2023-03-14 — — CN claimed
CN-115779140-B Wound dressing containing collagen and preparation method thereof 江苏亨瑞生物医药科技有限公司 2023-05-02 — — CN disclosed
CN-115779140-A Wound dressing containing collagen and preparation method thereof 江苏亨瑞生物医药科技有限公司 2023-03-14 — — CN disclosed
US-7868177-B2 Multi-cyclic compounds and method of use AMGEN INC. (US) 2011-01-11 — — US disclosed
EP-1994030-B1 MULTI-CYCLIC COMPOUNDS AND METHOD OF USE AMGEN INC (US) 2010-08-25 — — EP disclosed
US-7538115-B2 Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2009-05-26 — — US disclosed
US-20070213325-A1 Multi-cyclic compound and method of use AMGEN INC. (US) 2007-09-13 — — US disclosed
EP-1487821-B1 BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES BOEHRINGER INGELHEIM PHARMA (DE) 2007-03-21 — — EP disclosed
US-7026312-B2 Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2006-04-11 — — US disclosed
US-20050215546-A1 Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-09-29 — — US disclosed
EP-1487821-A1 BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES Boehringer Ingelheim Pharma GmbH & Co.KG (DE) 2004-12-22 — — EP disclosed
US-20030236282-A1 Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof BOEHRINGER INGELHEIM PHARMA GMBH & CO. (DE) 2003-12-25 — — US disclosed
WO-2003076432-A1 BENZODIAZEPINE-SUBSTITUTED PIPERIDINES FOR UTILIZATION IN THE TREATMENT OF CARDIOVASCULAR DISEASES BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2003-09-18 — — WO disclosed
US-6204264-B1 Benzimidazole derivative, hair growth promoter and external composition for skin using the same SHISEIDO CO., LTD. (JP) 2001-03-20 — — US disclosed
EP-0989123-A1 Benzimidazole derivative, hair growth promoter and external composition for skin using the same SHISEIDO COMPANY LIMITED (JP) 2000-03-29 — — EP disclosed
US-4053472-A MICROBIOCIDES SCHERING AKTIENGESELLSCHAFT (DT) 1977-10-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070213325-A1 Multi-cyclic compound and method of use TIE1, CDK1, CCNB1 POLB 2077/4885RAD52 2607/4885KMT2A 643/4885
US-20030236282-A1 Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof P2RX5, CALCRL, ADRA1D POLB 2809/4885RAD52 4488/4885KMT2A 4809/4885
US-20050215546-A1 Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof P2RX3, P2RX5, P2RX2 POLB 2760/4885RAD52 3754/4885KMT2A 4767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.