Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993860 | 0.89 | ALOX5 (0.67) | HDAC2ALOX5PTGS1PTGS2NPC1 | |
| SCHEMBL10457551 | 0.89 | ALOX5 (0.67) | HDAC2ALOX5PTGS1PTGS2NPC1 | |
| SCHEMBL9590158 | 0.88 | HDAC2 (0.59) | HDAC2NPC1L3MBTL1TRPM8 | |
| SCHEMBL10876301 | 0.85 | ALOX5 (0.68) | HDAC2ALOX5PTGS1PTGS2NPC1 | |
| SCHEMBL9877335 | 0.80 | TRPM8 (0.60) | ALOX5PTGS1PTGS2TRPM8 | |
| SCHEMBL11280949 | 0.80 | NPC1 (0.81) | HDAC2NPC1L3MBTL1TRPM8 | |
| SCHEMBL11280951 | 0.80 | NPC1 (0.81) | HDAC2NPC1L3MBTL1TRPM8 | |
| SCHEMBL10569133 | 0.79 | HSD11B1 (0.60) | ALOX5PTGS1PTGS2 | |
| SCHEMBL8997381 | 0.79 | ALOX5 (0.50) | HDAC2ALOX5NPC1L3MBTL1TRPM8 | |
| SCHEMBL8997385 | 0.79 | ALOX5 (0.50) | HDAC2ALOX5NPC1L3MBTL1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |