Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9743002 | 0.91 | CHRM5 (0.46) | CHRM5EPHX2MAPTOPRL1SLC6A4 | |
| SCHEMBL9744554 | 0.88 | CHRM5 (0.43) | CHRM5EPHX2OPRL1 | |
| SCHEMBL9742586 | 0.87 | HTT (0.38) | CHRM5MAPTSLC6A4CCR2SLC6A3 | |
| SCHEMBL9738601 | 0.86 | CHRM5 (0.53) | CHRM5MAPTSLC6A4CCR2OPRM1 | |
| SCHEMBL9743342 | 0.85 | PSEN1 (0.40) | CHRM5MAPTOPRM1 | |
| SCHEMBL9743436 | 0.84 | GRIN1 (0.39) | CHRM5EPHX2MAPT | |
| SCHEMBL9742428 | 0.83 | LMNA (0.37) | CHRM5MAPT | |
| SCHEMBL9744919 | 0.81 | HTT (0.40) | CHRM5SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9742113 | 0.80 | CHRM5 (0.43) | CHRM5SLC6A4OPRK1SLC6A3SLC6A2 | |
| SCHEMBL9742447 | 0.79 | ADAM17 (0.40) | CHRM5OPRM1OPRK1SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016529-A1 | NOVEL ISOINDOLE DERIVATIVES AND MEDICAMENTS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-10-01 | — | — | WO | disclosed |