Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9743835 | 0.79 | ALDH1A1 (0.43) | ALOX5EGFRTUBB4ATUBBTUBA3C | |
| SCHEMBL9209888 | 0.75 | PDK1 (0.55) | ALOX5CYP1A2CYP2D6MAPTALDH1A1 | |
| SCHEMBL9439285 | 0.74 | ALOX5 (0.60) | ALOX5CYP1A2CYP2D6LMNACYP3A4 | |
| SCHEMBL9743956 | 0.74 | ALOX5 (0.48) | ALOX5MAPTLMNATP53ALDH1A1 | |
| SCHEMBL9186859 | 0.73 | ALOX5 (0.54) | ALOX5HSP90AA1HSP90AB1PSMB8CYP1A2 | |
| SCHEMBL9743792 | 0.72 | PSMB8 (0.39) | ALOX5HSP90AA1HSP90AB1PSMB8ALDH1A1 | |
| SCHEMBL9386156 | 0.70 | PSMB8 (0.52) | ALOX5HSP90AA1HSP90AB1PSMB8CYP1A2 | |
| SCHEMBL9209931 | 0.70 | ALOX5 (0.37) | ALOX5MAPTLMNATP53 | |
| SCHEMBL9744730 | 0.70 | HSP90AA1 (0.56) | ALOX5HSP90AA1HSP90AB1PSMB8CYP1A2 | |
| SCHEMBL11206376 | 0.70 | PSMB8 (0.47) | ALOX5HSP90AA1HSP90AB1PSMB8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171746-A | THIAZOLE AND IMIDAZOLE DERIVATIVES AND ANTIULCER COMPOSITION CONTAINING SAME | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1992-12-15 | — | — | US | disclosed |
| EP-0452076-A1 | Thiazole and imidazole derivatives and antiulcer composition containing same | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1991-10-16 | — | — | EP | disclosed |