Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.39 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748582 | 0.83 | NR4A1 (0.44) | PGRNR4A1LMNAMAPTKMT2A | |
| SCHEMBL23835719 | 0.75 | PGR (0.52) | PGRLMNAMAPTKDM4EKMT2A | |
| SCHEMBL2987129 | 0.70 | ALDH1A1 (0.44) | PGRMAPTKMT2APOLBALDH1A1 | |
| SCHEMBL10949720 | 0.70 | ALDH1A1 (0.34) | LMNAMAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL9747889 | 0.70 | AKR1C3 (0.44) | LMNAMAPTKDM4EKMT2AHPGD | |
| SCHEMBL9748600 | 0.70 | KMT2A (0.41) | PGRNR4A1MAPTKMT2AHPGD | |
| SCHEMBL9667223 | 0.68 | ALDH1A1 (0.45) | MAPTKDM4EKMT2AHPGDPOLB | |
| SCHEMBL11478104 | 0.68 | AKR1C3 (0.39) | MAPTKMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9748589 | 0.68 | KMT2A (0.39) | PGRNR4A1LMNAMAPTKMT2A | |
| SCHEMBL28381581 | 0.68 | AKR1C3 (0.41) | LMNAMAPTKMT2AHPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221753-B1 | TRANSDERMAL TREATMENT FOR PAIN AND INFLAMMATION WITH 2-AMINO-3-AROYLBENZENEACETIC ACIDS, SALTS AND ESTERS | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4683242-A | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-07-28 | — | — | US | disclosed |
| EP-0221753-A2 | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-05-13 | — | — | EP | disclosed |