Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17066928 | 0.83 | MEN1 (0.44) | ALDH1A1MEN1KMT2APGRCREBBP | |
| SCHEMBL23835719 | 0.81 | PGR (0.52) | ALDH1A1MEN1KMT2APGRDAO | |
| SCHEMBL24112725 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2APGRCREBBP | |
| SCHEMBL24112230 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2APGRCREBBP | |
| SCHEMBL17066904 | 0.76 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2APGRCRBN | |
| SCHEMBL23501955 | 0.75 | PGR (0.33) | ALDH1A1MEN1KMT2APGRCREBBP | |
| SCHEMBL2693278 | 0.73 | IDO1 (0.64) | ALDH1A1PGRCREBBPMAPTIDO1 | |
| SCHEMBL11368672 | 0.72 | DAO (0.40) | ALDH1A1MEN1KMT2ACREBBPDAO | |
| SCHEMBL24019657 | 0.72 | TP53 (0.40) | ALDH1A1MEN1KMT2ACREBBPDAO | |
| SCHEMBL24029075 | 0.72 | TP53 (0.40) | ALDH1A1MEN1KMT2ACREBBPDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-7786129-B2 | Piperazine derivatives of dialkyl oxindoles | EGIS GYOGYSZERGYAR NYRT (HU) | 2010-08-31 | — | — | US | disclosed |
| US-20090281137-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | VOLK BALAZS | 2009-11-12 | — | — | US | disclosed |
| EP-1776339-B1 | 3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2009-07-01 | — | — | EP | disclosed |
| EP-1751138-B9 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2008-11-12 | — | — | EP | disclosed |
| EP-1751138-B1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2007-12-26 | — | — | EP | disclosed |
| US-20070232662-A1 | Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders | EGIS GYOGYSZERGYAR RT. (HU) | 2007-10-04 | — | — | US | disclosed |
| US-20070232619-A1 | Piperazine Derivatives of Dialkyl Oxindoles | EGIS GYOGYSZERGYAR RT. (HU) | 2007-10-04 | — | — | US | disclosed |
| EP-1776339-A2 | 3-(((4-PHENYL)-PIPERAZIN-1-YL)-ALKYL)-3-ALKYL-1,3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS Gyógyszergyár Nyrt (HU) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005109987-A9 | 3-(((4-PHENYL)-PIPERAZINE-1-YL)-ALKYL)-3-ALKYL-1, 3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS GYOGYSZERGYAR NYRT (HU) | 2007-03-29 | — | — | WO | disclosed |
| EP-1751138-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS Gyógyszergyár Nyrt (HU) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005109987-A2 | 3-(((4-PHENYL)-PIPERAZINE-1-YL)-ALKYL)-3-ALKYL-1, 3-DIHYDRO-2H-INDOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYÁR NYRT. (HU) | 2005-11-24 | — | — | WO | disclosed |
| WO-2005108390-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | EGIS GYÓGYSZERGYÁR NYRT. (HU) | 2005-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232619-A1 | Piperazine Derivatives of Dialkyl Oxindoles | TPH2, DRD3, CNR2 | ALDH1A1 462/4885MEN1 2425/4885KMT2A 2483/4885 |
| US-20070232662-A1 | Indol-2-One Derivatives for the Treatment of Central Nervous Disorders, Gastrointestinal Disorders and Cardiovascular Disorders | TPH2, TPH1, IDO1 | ALDH1A1 659/4885MEN1 1071/4885KMT2A 2428/4885 |
| US-20090281137-A1 | INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS | TPH2, TPH1, IDO1 | ALDH1A1 649/4885MEN1 961/4885KMT2A 2376/4885 |
| US-20230212152-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | CTRL, CTSL, CTSV | ALDH1A1 1863/4885MEN1 4306/4885KMT2A 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.