Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313060 | 0.83 | CYP4F2 (0.47) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL379262 | 0.81 | MEN1 (0.50) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL17212019 | 0.81 | MEN1 (0.41) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL13622353 | 0.81 | MEN1 (0.41) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL31265512 | 0.80 | PKM (0.38) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL20211699 | 0.79 | MEN1 (0.53) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL1315228 | 0.78 | CYP4F2 (0.50) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL15551008 | 0.78 | MMP8 (0.43) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL18541186 | 0.78 | CYP4F2 (0.50) | MMP8MEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL9623535 | 0.78 | MMP8 (0.43) | MMP8MEN1KMT2ACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213293-B1 | 11-Substituted 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1992-01-02 | — | — | EP | disclosed |
| US-4724236-A | FOR TREATING THROMBOEBOLIC DISEASE, BRADYCARDIA OR BRADYARRYTHMIA | KARL THOMAE GMBH (DE) | 1988-02-09 | — | — | US | disclosed |
| EP-0213293-A2 | 11-Substituted 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1987-03-11 | — | — | EP | disclosed |