Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9748657 | 0.83 | MMP8 (0.44) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL17212019 | 0.81 | MEN1 (0.41) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL13622353 | 0.81 | MEN1 (0.41) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL379262 | 0.81 | MEN1 (0.50) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL31265512 | 0.80 | PKM (0.38) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL1316720 | 0.78 | ALDH1A1 (0.37) | ALDH1A1CYP3A4 | |
| SCHEMBL6893301 | 0.78 | CYP4F2 (0.46) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL1265697 | 0.78 | CYP4F2 (0.46) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL18541186 | 0.78 | CYP4F2 (0.50) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL1315228 | 0.78 | CYP4F2 (0.50) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043423-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2024-02-08 | — | — | US | disclosed |
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2023-08-08 | — | — | US | disclosed |
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2023-08-08 | — | — | US | disclosed |
| CN-113329996-B | Compounds and methods for treating hedgehog pathway related disorders | 博远医药(苏州)有限公司 | 2023-03-10 | — | — | CN | disclosed |
| CN-113329996-A | Compounds and methods for treating hedgehog pathway related disorders | 苏州麦迪耐斯医药科技有限公司 | 2021-08-31 | — | — | CN | disclosed |
| US-20210214353-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SUZHOU MEDNES PHARMA TECH CO., LTD. (CN) | 2021-07-15 | — | — | US | disclosed |
| EP-3810573-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | Suzhou Mednes Pharma Tech Co., Ltd. (CN) | 2021-04-28 | — | — | EP | disclosed |
| US-9771325-B2 | Tricyclic compounds and preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-09-26 | — | — | US | disclosed |
| US-9771325-B2 | Tricyclic compounds and preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-09-26 | — | — | US | disclosed |
| US-20160362371-A1 | NOVEL TRICYCLIC COMPOUNDS AND PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-12-15 | — | — | US | disclosed |
| WO-2006002802-A1 | PHENYL DERIVATIVES COMPRISING AN ACETYLENE GROUP | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| US-20060004091-A1 | Phenyl derivatives comprising an acetylene group | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-05 | — | — | US | disclosed |
| CN-1043042-C | Cephalosporins derivatives and process for preparing them | HOECHST AG (DE) | 1999-04-21 | — | — | CN | disclosed |
| US-RE34865-E | Antibiotics | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-02-21 | — | — | US | disclosed |
| US-5280044-A | Fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0381330-B1 | Fungicides | ZENECA LTD (GB) | 1993-12-29 | — | — | EP | disclosed |
| US-5100887-A | Bactericides | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-03-31 | — | — | US | disclosed |
| US-4999381-A | Fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-03-12 | — | — | US | disclosed |
| EP-0381330-A1 | Fungicides | ZENECA LIMITED (GB) | 1990-08-08 | — | — | EP | disclosed |
| CN-1035509-A | Cynnematin analog derivative and preparation method thereof | HOECHST AG (DE) | 1989-09-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718614-B2 | Compounds and methods for treatment of hedgehog pathway associated conditions | SHH, GLI1, SMO | CYP4F2 1000/4885CYP4A11 553/4885MEN1 1143/4885 |
| US-20240043423-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SHH, GLI1, SMO | CYP4F2 1048/4885CYP4A11 469/4885MEN1 1059/4885 |
| US-20160362371-A1 | NOVEL TRICYCLIC COMPOUNDS AND PREPARATION THEREOF | CYP11B1, CYP11B2, CYP51A1 | CYP4F2 61/4885CYP4A11 5/4885MEN1 462/4885 |
| US-20060004091-A1 | Phenyl derivatives comprising an acetylene group | PPARD, PPARA, PPARG | CYP4F2 441/4885CYP4A11 112/4885MEN1 4406/4885 |
| US-20210214353-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS | SHH, GLI1, SMO | CYP4F2 1000/4885CYP4A11 553/4885MEN1 1143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.